Simulating macroscale brain circuits with microscale resolution

Simulating macroscale brain circuits with microscale resolution

A Spotlight on Bridging Microscale and Macroscale Human Brain Architecture

We place a spotlight on the emerging trend of jointly studying the micro- and macroscale organization of nervous systems. We discuss the pioneering studies of Ding et al. (2016) and Glasser et al. (2016) in the context of growing efforts to combine and integrate multiple features of brain organization into a multi-modal and multi-scale examination of the human brain.

Resolving macroscale and microscale heterogeneity in virus filtration

In this paper, we characterize the filtration and deposition profiles of a recombinant analog of Norwalk virus, an important waterborne pathogen, in packed beds of saturated quartz sand under both ‘clean-bed’ and ‘dirty-bed’ conditions. Under clean-bed conditions with NaCl as the electrolyte, the retained Norwalk virus particles decline like a power-law with depth. The power-law decay in retain...

A Review on Macroscale and Microscale Cell Lysis Methods

The lysis of cells in order to extract the nucleic acids or proteins inside it is a crucial unit operation in biomolecular analysis. This paper presents a critical evaluation of the various methods that are available both in the macro and micro scale for cell lysis. Various types of cells, the structure of their membranes are discussed initially. Then, various methods that are currently used to...

Patch Dynamics for Multiscale Problems Bridging the Macroscale and Microscale

There are important systems—those that couple molecular dynamics with a material’s macroscale behavior or use a Boltzmann particle model to predict large-scale patterns in a fluid flow, for example—that must be modeled on relatively long time or space scales, but the dynamics can be advanced only on short time or space scales. First developed by Yannis Kevrekidis and his collaborators,1–5 patch...